New Alzheimer’s Test Can Predict Age of Disease’s Onset:
A new genetic test can predict at what age a person with risk factors is likely to develop Alzheimer’s disease. The Polygenic Hazard Score test, developed by an international team led by University of California researchers, issues patients a score based on 31 genetic markers. A study published Tuesday in PLoS Medicine
, found that a high score on the PHS scale can mean a diagnosis years before those who have a low-risk genetic profile. The latest studyindicates that thousands of background genetic variations have small influences on Alzheimer’s risk when considered separately, but those same variants have a substantial cumulative influence. The test was created by using the genetic data of more than 70,000 people, including healthy elderly individuals and actual patients who were already diagnosed with Alzheimer’s. Rahul Desikan
, of the University of California, says the test can now be used to calculate any person’s risk of developing the disease that year. “That is, if you don’t already have dementia, what is your yearly risk for AD onset, based on your age and genetic information?” he added.
Shots, Explosions Reported Outside of U.K. Parliament:
Local reporters at the House of Parliament in London reported shootings and explosions outside Westminster Hall and near the Westminster bridge. Christopher Hope
, assistant editor and chief political correspondent at The Daily Telegraph
, tweeted that journalists were told to stay in their offices in the Press Gallery. A Reuters photographer reported seeing a vehicle hitting pedestrians on the Westminster bridge.
Report: Manafort Secretly Worked for Russian Billionaire:
, President Trump
’s former campaign chairman, secretly worked for a Russian billionaire to “greatly benefit the Putin government,” according to documents obtained by the Associated Press. The new report directly contradicts the Trump administration and Manafort, who have both alleged that the former campaign operative never worked on behalf of Russian interests. In his work for a close confidant of Russian President Vladimir Putin
, Russian aluminum magnate Oleg Deripaska
, he strategized in June 2005 that he would influence politics and business dealings in Europe and the U.S. to positively benefit Putin’s government. Manafort eventually signed a $10 million annual contract with Deripaska, and the two maintained a business relationship up until at least 2009. Manafort confirmed to the AP that he worked for Deripaska but said his work was being unfairly criticized as “inappropriate or nefarious” by a “smear campaign.” Manafort resigned from his position as Trump’s campaign chairman last August after press reports surfaced showing that he had, until 2014, organized a secret Washington lobbying operation on behalf of Ukraine’s pro-Russia political party.
Trump to Attend NATO Summit:
is set to attend a NATO summit in Brussels in May to “reaffirm” U.S. commitment to the alliance. White House press secretary Sean Spicer confirmed the news late Tuesday, saying Trump “looks forward to meeting with his NATO counterparts to reaffirm our strong commitment to NATO, and to discuss issues critical to the alliance, especially allied responsibility-sharing and NATO’s role in the fight against terrorism.” The announcement follows mounting concerns over U.S. commitment to the alliance, after Trump repeatedly criticized other member states and once described NATO as “obsolete.” On Saturday, he lamented on Twitter that it was “very unfair” to the U.S. that NATO member states were not contributing more to defense, claiming Germany owes “vast sums” of money. Concerns also intensified Monday when Reuters reported that U.S. Secretary of State Rex Tillerson
planned to skip a NATO meeting in early April—his first meeting with NATO foreign ministers. Just as the White House announced Trump’s attendance of the NATO summit on Tuesday, however, the State Department said Tillerson still hoped to meet with NATO foreign ministers and had already proposed new dates for his meeting. “We are certainly appreciative of the effort to accommodate Secretary Tillerson,” State Department spokesman Mark Toner
said, referring to the alliance’s attempt to reschedule the meeting at a more convenient time. “We have offered alternative dates that the secretary could attend,” Toner said, according to Reuters. Toner also reassured that “the United States remains 100 percent committed” to the alliance.
U.S. Makes Its First World Baseball Championship Final:
The U.S. has earned its first trip to a World Baseball Classic championship game after beating Japan 2-1 on Tuesday night. Team USA will face Puerto Rico on Wednesday at Dodger Stadium in a winner-take-all final. The U.S., in three previous tournaments, had once advanced to the semifinals but never made it further. On Tuesday, however, Japan’s team made a few defensive mistakes and Team USA pounced. Andrew McCutchen
, who drove in an early run for the U.S. on Tuesday, said the win “means a heckuva lot.” He added, “We have a great group of guys on this team who have dedicated this time to be able to try and win some ballgames. A sacrifice had to be made. There are no egos when that door opens, and that is what is good about this team.”
#DeleteUber Led to 500K Deletions:
According to a report in The New York Times
, the grassroots #DeleteUber campaign resulted in about half a million requests to delete the app in the week following the beginning of thecampaign in January. Three people familiar with the internal metrics provided the Times
these figures. The #DeleteUber campaign began after the company appeared to try to capitalize on a New York City taxi work stoppage that was in solidarity with activists at airports protesting the Trump administration’s first executive order banning travelers from Muslim-majority nations. In a conference call Uber had with reporters Tuesday, the ride-hailing company said it was seeking a chief operating officer to help Chief Executive Travis Kalanick
. “The board is confident in Travis, and we are proceeding ahead with the search for the COO,” board memberArianna Huffington
said during the call. “Put very simply, change starts at the top.”
LBN GETS STORY OUT BEFORE CNN, NEW YORK TIMES, ASSOCIATED PRESS: Chicago Police: Dozens Watched Teen’s Sexual Assault on Facebook Live. Late yesterday, LBN released this incredibly horrible story to all its readers in all 50 of the United States an 26 foreign countries beating major news outlets like CNN, The New York Times and Associates Press.
LBN-SNAPSHOT (Exclusive LBN photo): Media expert and author Michael Levine – www.MichaelLevineMedia.com
Chuck Barris, of ‘Gong Show,’ Dies at 87:
, the multi-talented impresario and creator of The Dating Game
and The Newlywed Game
, died Tuesday in Palisades, New York, at the age of 87. Barris died of natural causes, according to his publicist. He was a show creator and songwriter, and he wrote hits like “Palisades Park,” which made it to No. 3 on the Billboard Hot 100 chart. Barris’s autobiography, Confessions of a Dangerous Mind
, also became a film, which starred Sam Rockwell
as Barris and was directed by George Clooney
. His book was criticized for some inaccuracies, including a claim that he worked for the CIA. “He also fabricated his life because it might have been the best way of getting at the truth,” said Joel Stein
magazine. “The truth was that back when he was the Jerry Springer of his day, he couldn’t stomach being attacked for doing something he considered harmless.” In 1976, he became the host of TV’sThe Gong Show,
a famously out-there talent show that was so popular it inspired a feature film.
LBN-HEALTH WATCH: ***Taking 10,000 steps per day is often suggested as a desirable exercise goal for people who wish to improve their health. But a new study of postal workers in Scotland suggests that that number could be too conservative and that, to best protect our hearts, many of us might want to start moving quite a bit more. It has been almost 70 years since the publication of the London Transit Workers Study, a famous work in which researchers tracked the heart health of London bus drivers and conductors. They found that the conductors, who walked up and down bus aisles throughout the workday, were substantially less likely to develop or die from heart disease than the drivers, who sat almost constantly while at work.
LBN-NOTICED: ***Finding a pair of well-fitting pants remains a challenge for Ben Affleck. On Tuesday, the bearded “Justice League” star picked up daughters Violet, 11, and Seraphina, 8, from their Santa Monica, Calif., school in a pair of saggy slacks. Pairing baggy jeans with a dark jacket and gray sneakers, Affleck, 44, led the way in the rain as he and his girls headed to the car nearby.
LBN-R.I.P.: ***Jerry Krause, the general manager who orchestrated the Chicago Bulls’ dynasty of the 1990s, assembling the teams that Michael Jordan led to six N.B.A. championships, has died. He was 77. The Bulls announced his death on Tuesday, giving no other details. The Chicago Tribune reported that he had been treated for osteomyelitis, a bone infection, among other health problems.
LBN-COMMENTARY by Thomas L. Friedman: Memo To: Secretary of Defense James Mattis, National Security Adviser H. R. McMaster, Secretary of Homeland Security John Kelly, C.I.A. Director Mike Pompeo and Secretary of State Rex Tillerson. Dear Sirs, I am writing you today as the five adults with the most integrity in the Trump administration. Mattis, McMaster and Kelly, you all served our nation as generals in battle. Pompeo, you graduated first in your class at West Point and served as a cavalry officer. Tillerson, you ran one of America’s largest companies. I am writing you directly because I believe you are the last “few good men” who can stand up and reverse the moral rot that has infected the Trump administration from the top. The last time our country faced such a cancer on the presidency, the Republican Party’s leadership stood up and put country before party to get to the truth. But today’s G.O.P. is a pale imitation of that party. With a few exceptions, it has declared moral bankruptcy and abdicated its responsibility to draw any red lines for President Trump.
LBN-COMMENTARY by Frank Bruni: Donald Trump faces a stark choice. He can tweet, or he can govern. He can indulge his persecution complex, firing off missives that compare Barack Obama to Joseph McCarthy and American intelligence officers to Nazis, or he can recognize it as a gateway to disgrace and irrelevance. He can make his presidency about his own viscera, or he can make it about the country’s welfare. He can do what feels cathartic in the moment, or he can do what’s constructive in the long run. He can dabble in bright colors and shiny objects, or he can deal in durable truths. I’m focusing on Twitter because it teases out his worst traits. It’s the theater for vainglorious, vindictive, impulsive Trump, and it was the realm in which he made the wild accusations that Obama had wiretapped Trump Tower. On Monday, James Comey debunked those charges, certifying them as the gaseous fulminations we more or less knew they were.
LBN-OVERHEARD: ***Lindsay Lohan is once again ready for her close up. After a lengthy period away television and movies, the 30-year-old is plotting her return with a social-media themed show titled “The Anti-Social Network.” “I’m back, bitches!” Lohan announces in a video teaser. According to a press release, Lohan is currently shopping the show to networks. ***Elizabeth Olsen‘s spring fling is heating up. On Monday, the “Avengers” beauty strolled through New York on the arm of new beau, singer-songwriter Robbie Arnett.
LBN – A DIFFERENT VIEW…
LBN E-Lert Edited By Addison Beaulieu
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